Vascular Access Conversation - IVUPDATE Podcast from IVTEAM

"Nevertheless, as far as bacterial adhesion is concerned, after the catheter was locked and the lock removed, the surface modifications promoted no adhesion" Khzam et al (2023).

Bacterial adhesion on polyurethane central catheters

Abstract:

It was shown in the literature that ethanol locks have a positive effect on preventing catheter-related infections in patients with central venous catheters without causing any microbial resistance. However, ethanol is known to interact with polyurethanes. The consequences of this interaction on the catheter surface properties were studied as it can impact the biocompatibility of the material and the adhesion phenomena onto the surface. No physical and chemical degradation was put into evidence, but low molecular weight compounds such as additives were extracted from the catheter bulk or migrated and exudated onto its surface. Nevertheless, as far as bacterial adhesion is concerned, after the catheter was locked and the lock removed, the surface modifications promoted no adhesion.


Reference:

Khzam A, Saunier J, Guilbaud M, Herry JM, Dazzi A, Tortolano L, Carpentier L, Mignot A, Yagoubi N. Surface properties and bacterial adhesion on polyurethane central catheters: Impact of ethanol lock solution. Biomater Adv. 2023 Jan 6;146:213281. doi: 10.1016/j.bioadv.2023.213281. Epub ahead of print. PMID: 36634377.