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"To evaluate hemostatic changes in patients undergoing hemodialysis with prolonged use of CVC or AVF" Cunha et al (2022).

AV fistula or CVC for hemodialysis

Abstract:

Background: Failure to mature the fistula in patients undergoing hemodialysis leads to prolonged use of the central venous catheter (CVC) and can compromise the patency of the catheter and the arteriovenous fistula (AVF) due to thrombus development.

Objective: to evaluate hemostatic changes in patients undergoing hemodialysis with prolonged use of CVC or AVF.

Method: cross-sectional study with a total of 200 adult participants who were divided into the following groups: I:control; II: patients who had 5 to 8 months of CVC insertion; III: patients who had 9 to 36 months of insertion; IV patients who had 5 to 8 months of AVF and V: patients who had 9 to 36 months of AVF. Platelet activation was investigated by expressions of GPIIb/IIIa and p-selectin using flow cytometry. The Elisa-thrombomodulin test was used to compare groups III and V.

Results: the p-selectin percentage expression of group I was 15.30 (12.30-16.80), II 23.25 (20.75-30.55) and III 54.00 (44.75 -59.29) were significant (p<0.001). Groups I, IV and V were also significant (p<0.001). The median fluorescence for GPIIb/IIIa for groups I, II and III were significant (p<0.0001). As for the Elisa test, an increased absorbance of thrombomodulin was verified in patients who used the CVC 4372 (3951-4733) when compared to those patients who used the AVF 2162 (1932-2485) (p<0.0001).

Conclusion: It can be concluded that CVC patients had a larger platelet expression of GPIIb/IIIa and p-selectin than AVF patients. The high concentration of thrombomodulin in CVC patients may suggest a greater stimulation of the intrinsic than extrinsic coagulation pathways.


Reference:

Cunha MD, Ottoni MHF, da Silva NC, Araújo SJT, Duarte RCF, Lucas TC. Hemostatic changes in patients undergoing hemodialysis: Differences between central venous catheters and arterio-venous fistulas. Artif Organs. 2022 Apr 22. doi: 10.1111/aor.14268. Epub ahead of print. PMID: 35451088.