Abstract:
Extract:
“This letter highlights the experience of once daily (OD) parenteral ceftriaxone in neonates referred to OPAT Service at the Children’s Hospitals in Bristol, Southampton, Belfast, Alder Hey and Sheffield, and proposes that, with appropriate monitoring, this is a safe and effective treatment strategy.
As OD broad-spectrum antimicrobial with good central nervous system penetration, ceftriaxone has practical benefits over other antibiotics used to treat bacterial infections in babies and children, including reduced length of hospital stay due to administration in the community. It is generally well tolerated, with main adverse events known to include reversible cholelithiasis.”
Reference:
King H, Walsgrave K, Patel S, Green H, Moriarty P, Dawson N, Gillespie M, Porter D, Crouch C, Bernatoniene J. Ceftriaxone to enable paediatric outpatient antimicrobial treatment (OPAT) in neonates. Arch Dis Child. 2024 Sep 12:archdischild-2024-327621. doi: 10.1136/archdischild-2024-327621. Epub ahead of print. PMID: 39266285.