Minocycline-EDTA-Ethanol antimicrobial catheter lock solution

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"We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for eradication of biofilm of 10 C. auris strains" Reitzel et al (2020).

Abstract:

Candida auris is an emerging pathogen that can cause virulent central line associated bloodstream infections. Catheter salvage through eradicating biofilm is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for eradication of biofilm of 10 C. auris strains. MEE fully eradicated all C. auris biofilms while taurolidine lock partially eradicated all of the C. auris biofilms. The superiority was significant for all C. auris strains tested (p=0.002).

Reference:

Reitzel, R.A., Rosenblatt, J., Gerges, B.Z., Vargas-Cruz, N. and Raad, I.I. (2020) Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution is highly effective in vitro for Eradication of Candida auris Biofilms. Antimicrobial Agents and Chemotherapy. January 13th. doi: 10.1128/AAC.02146-19. .

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