Abstract:
Abstract:
Objective: The objective of this study was to systematically analyse the incidence and influencing factors of medical adhesive-related skin injury (MARSI) in critically ill patients.
Methods: A systematic search of eight databases was conducted from their inception to October 10, 2025. Two trained researchers independently performed study screening, data extraction, and quality assessment. Statistical analyses were performed using R software. We performed meta-analyses to pool the incidence of MARSI and its influencing factors using a random-effect model. Subgroup and sensitivity analyses were conducted to explore heterogeneity and verify robustness.
Results: A total of 20 studies involving 4337 patients were included in this review. The pooled incidence of MARSI among intensive care unit patients was 25.21% (95% confidence interval [CI] = [17.99, 34.12]). Of all subtypes, skin stripping had the highest incidence, at 52.19% (95% CI = [39.69, 64.42]). This analysis identified eight factors significantly associated with MARSI: length of hospital stay (standardised mean difference = 0.562, 95% CI = [0.290, 0.835]), fever (odds ratio [OR] = 2.306, 95% CI = [1.540, 3.454]), skin oedema (OR = 5.739, 95% CI = [3.502, 9.405]), intravenous fluids (OR = 2.899, 95% CI = [1.550, 5.423]), mechanical ventilation (OR = 3.519, 95% CI = [2.128, 5.819]), sedatives (OR = 4.807, 95% CI = [1.798, 12.852]), antibiotics (OR = 2.427, 95% CI = [1.448, 4.066]), and Braden score (standardised mean difference = -0.424, 95% CI = [-0.635, -0.212]).
Conclusions: This systematic review and meta-analysis demonstrates a substantial incidence of MARSI in intensive care unit patients, with considerable variation in incidence rates across different MARSI subtypes. To mitigate the occurrence of MARSI, healthcare providers should prioritise early identification of at-risk patients based on established influencing factors.
Registration: This review protocol has been prospectively registered in the International Prospective Register of Systematic Reviews (CRD42024566852).
Reference:
Chen J, Yu P, Liu L, Chen M, Yuan X, Xu Y, Wang N, Zhu M. Incidence and influencing factors of medical adhesive-related skin injury in critically ill patients: A systematic review and meta-analysis. Aust Crit Care. 2026 Jan 22;39(2):101524. doi: 10.1016/j.aucc.2025.101524. Epub ahead of print. PMID: 41576831.