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"The ethanol lock did not cause any side effects and was relatively effective in preventing infections related to the central venous catheter" Falcão et al (2022).
Ethanol lock prophylaxis

Abstract:

The aim of this study was to report on use of ethanol lock in long-term catheters in newborns with severe intestinal dysfunction, dependent on total and prolonged parenteral nutrition, in a Neonatal Intensive Care Center (tertiary level), between 2015 and 2020. Six infants (0.65%) out of the 914 admitted during the period met the inclusion criteria. The median age at catheter placement was 121.5 days. Two Powerpicc (PICC Power Sinergy™, São Paulo), one Groshong (Groshong™ Central Venous Catheter BD, São Paulo), and three silicone catheters were used, all tunneled, and the median dwell duration was 182.5 days. Four patients had at least one episode of infection related to the central venous catheter, and Gram-positive, Gram-negative, and fungal agents were isolated. The median length of hospital stay was 555 days and mortality was 33.3%. The ethanol lock did not cause any side effects and was relatively effective in preventing infections related to the central venous catheter.

Reference:

Falcão MC, de Castro GIM, Framil JVS, Bigio JZD, Tannuri ACA. Ethanol lock prophylaxis in long-stay central venous catheters in children with severe intestinal dysfunction: a report of six cases. J Vasc Bras. 2022 Jul 6;21:e20210221. doi: 10.1590/1677-5449.202102211. PMID: 35911477; PMCID: PMC9296061.