Abstract:
Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.
Reference:Reidenberg BE, Jenkins SG, Crandon JL, Hurlburt E, Tan X, Rhomberg PR, Arends SJR, Pfaffle A. In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections. Antimicrob Agents Chemother. 2024 Jun 12:e0038124. doi: 10.1128/aac.00381-24. Epub ahead of print. PMID: 38864612.