Insulin adsorption in ICU infusion sets

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Insulin adsorption has been observed in ICU delivery lines, and is especially problematic in the delivery of insulin within the neonatal ICU” Knopp et al (2019).

Abstract:

Insulin adsorption has been observed in ICU delivery lines, and is especially problematic in the delivery of insulin within the neonatal ICU. This paper presents a two state model with adsorptive loss described as a predator-prey term with parameters Ki and Beq. This model is discretized to N sub volumes along the length of an infusion set. The model was found to converge to a solution for N>~100-150. The model was fit to literature data, and it was found that the total adsorptive capacity of a material (Beq, U/m2) was hyperbolically related to flow rate. If the average rate constant Ki was used with the hyperbolic relationship, the model was able to describe adsorption dynamics at all 3 examined flow rates for a polyethylene line.

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Reference:

Knopp, J.L., Bishop, K. and Chase, J.G. (2019) A finite element model for insulin adsorption in ICU infusion sets. Conference Proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. July 2019, p.1682-1685. doi: 10.1109/EMBC.2019.8856797.

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