Our data suggest that p-OPAT is safe and effective, with the potential to offer considerable savings for the healthcare economy through reduced length of inpatient stay” Patel et al (2018).
BACKGROUND: Recent advances in outpatient parenteral antibiotic therapy (OPAT) have largely focused on adult practice, and there are few published data on the safety and effectiveness of pediatric OPAT (p-OPAT).
METHODS: During a 3-year-period (2012 to 2015), data were prospectively collected on patients managed within the p-OPAT service at Southampton Children’s Hospital, a tertiary pediatric hospital in the South of England.
RESULTS: A total of 130 p-OPAT episodes were managed during this period. The most frequently managed pathologies were bone and joint infections (44.6%), followed by ENT (10.7%), respiratory (10.0 %) and CNS (10.0 %) infections. The most frequently used antimicrobial agent was ceftriaxone (n=103;79.2%). For the majority of p-OPAT episodes, antimicrobials were delivered in pre-filled syringes (n=109; 83.8%); 24-hour infusions administered by elastomeric devices were used less commonly (n=16;12.3%). The median duration of p-OPAT treatment was 9.2 days (interquartile range: 7.6 – 19.0 days). With regard to patient outcomes, 113 (86.9%) p-OPAT episodes resulted in cure and 12 (9.2%) in improvement; treatment failure occurred in 5 (3.9%) episodes.Intravenous catheter-related complications were rare. A total of 1683 bed days were saved over the 3-year-period.
CONCLUSIONS: Our data suggest that p-OPAT is safe and effective, with the potential to offer considerable savings for the healthcare economy through reduced length of inpatient stay.
Patel, S., Burzio, V., Green, H., Rees, S., Tebruegge, M., Jones, C. and Faust, S.N. (2018) The Impact of Pediatric Outpatient Parenteral Antibiotic Therapy Implementation at a Tertiary Children’s Hospital in the United Kingdom. The Pediatric Infectious Disease Journal. April 2nd. .