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"Iron skin staining is a rare and potentially irreversible side effect of parenteral iron preparations due to cutaneous and subcutaneous tissue extravasation" Dias da Costa et al (2024).
Iron skin staining following IV iron infusion

Extract:

“Iron skin staining is a rare and potentially irreversible side effect of parenteral iron preparations due to cutaneous and subcutaneous tissue extravasation. The likelihood of ISS can be minimized by strictly following transparent administrative and monitoring protocols, ensuring comprehensive staff training, and offering patient information. Referral to a dermatology clinic for treatment with a nanosecond Q-switched laser or a picosecond laser may allow the hyperpigmentation to be attenuated.”

Reference:

Dias da Costa T, Mateus-Pinheiro A, Moreira S. Iron Skin Staining: A Rare but Permanent Complication Following IV Iron Infusion. Acta Med Port. 2024 Nov 18. doi: 10.20344/amp.22136. Epub ahead of print. PMID: 39556528.

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