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"She was started on TV at 2 mg/kg dose every 21 days. During cycle two of TV, her peripheral intravenous line in the right antecubital vein infiltrated after 23 ml of therapy" Son et al (2024).
Chemotherapy extravasation injury case study

Extract:

“A 62 year old woman was initially diagnosed with stage IVB PDL1 + squamous cell carcinoma of the cervix with bone, lung, and liver metastases. She underwent combination therapy with carboplatin, paclitaxel, bevacizumab, and pembrolizumab for ten cycles followed by bevacizumab maintenance and whole brain radiotherapy for brain metastasis. She had progression after four months with new metastatic lesions in multiple lymph nodes, liver, and lung. She was started on TV at 2 mg/kg dose every 21 days. During cycle two of TV, her peripheral intravenous line in the right antecubital vein infiltrated after 23 ml of therapy. Upon recognition, this line was removed, and a new peripheral line was started on the left forearm with infusion of the remainder of the medication. Five days later, the patient was seen in clinic for mild erythema and pain over the infiltration site (Fig. 1). She was started on topical clindamycin and cold compresses. Her symptoms continued, and twelve days post-infusion, she developed pustules and sloughing, which prompted admission to the hospital.”

Reference:

Son J, Cain KE, Marten CA, Dwyer KW, Sims TT, Taylor JS. Tisotumab vedotin extravasation injury in a patient with recurrent cervical cancer. Gynecol Oncol Rep. 2024 Oct 2;56:101525. doi: 10.1016/j.gore.2024.101525. PMID: 39431057; PMCID: PMC11490808.

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