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However, up to half of the children with acute lymphoblastic leukaemia will develop asymptomatic central venous line-related thromboembolism” Jarvis et al (2019).

Abstract:

Children with acute lymphoblastic leukaemia face increased risks of thromboembolism, and major risk factors for this serious treatment-related toxicity are central venous lines, asparaginase and steroids. Central venous lines have become standard care in paediatric oncology, facilitating therapy and improving patients’ quality of life. However, up to half of the children with acute lymphoblastic leukaemia will develop asymptomatic central venous line-related thromboembolism.

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Reference:

Jarvis, K.B., Tveiterås, M., De Lange, C. and Ruud, E. (2019) Central venous line-related thromboembolism is common in children with non-high risk acute lymphoblastic leukaemia. Acta Paediatrica. February 20th. [epub ahead of print].

doi: 10.1111/apa.14757