PICCs can be associated with T. pulmonis bacteremia, and fourth generation cephalosporins may be effective treatment” Suzuki et al (2017).
BACKGROUND: Tsukamurella pulmonis is an aerobic gram-positive and rod-shaped organism that causes central catheter-related bloodstream infections in immunocompromised hosts. However, peripherally inserted central catheter (PICC)-related bloodstream infections due to this organism have not been reported.
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CASE PRESENTATION: We describe a case of a 48-year-old man with acquired immunodeficiency syndrome and diffuse large B cell lymphoma who received five courses of chemotherapy including rituximab , cyclophosphamide , doxorubicin hydrochloride , vincristine , and prednisone via a PICC. Five days after the last chemotherapy course, he presented with a high fever and shaking chills. His absolute neutrophil count was 4200/μL. Cultures obtained from blood and PICC culture revealed T. pulmonis. The colony count of T. pulmonis grown from PICC culture was 103 colony-forming units. Therefore, he was diagnosed with T. pulmonis bacteremia resulting from PICC-related bloodstream infection. The patient’s condition improved and he became afebrile within 48 h after intravenous administration of cefozopran hydrochloride, which is a fourth generation cephalosporin.
CONCLUSIONS: PICCs can be associated with T. pulmonis bacteremia, and fourth generation cephalosporins may be effective treatment.Full Text
Suzuki, J., Sasahara, T., Toshima, M. and Morisawa, Y. (2017) Peripherally inserted central catheter-related bloodstream infection due to Tsukamurella pulmonis: a case report and literature review. BMC Infectious Diseases. 17(1), p.677.
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