Oral vancomycin induced flushing syndrome – Full Text

“Oral vancomycin is a first-line treatment for CDI. Vancomycin has been widely reported to induce flushing syndrome (also known as Red man syndrome), a well-known hypersensitivity reaction mostly occurs after intravenous administration. However, a few cases of flushing syndrome due to oral vancomycin have been reported” Zeng et al (2024).

Red man syndrome

“Red man syndrome (RMS) is a non-IgE-mediated anaphylactoid adverse event frequently witnessed after a rapid infusion of vancomycin” M Shaju et al (2022).

Vancomycin-induced red man syndrome presentation in a preterm infant

Given the wide use of vancomycin for the treatment of neonatal infections, a good awareness of red man syndrome signs and symptoms in the neonatal population is fundamental to recognize this adverse drug reaction and manage its rare but possible life-threatening complications” Martini et al (2018). Abstract: A male infant born at 32 weeks’ gestation […]