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"The use of the IO route is supported primarily though animal models of cardiac arrest and there is limited human data to confirm its effectiveness" Neth and Daya (2021).

Vascular access during cardiac arrest

Abstract:

Pharmacological agents such as epinephrine and antiarrhythmics are an integral part of resuscitation therapy in out-of-hospital cardiac arrest (OHCA) and their early administration has been associated with improved outcomes. Current international guidelines recommend the use of either intravenous (IV) or intraosseous (IO) routes for medication administration during cardiac arrest. The proximal tibial IO route is easy to access with a high success rate and often used as a primary or secondary vascular access site after failed peripheral IV access in many EMS systems. The use of the IO route is supported primarily though animal models of cardiac arrest and there is limited human data to confirm its effectiveness. In recent years, observational studies examining the effectiveness of the IO versus IV route on OHCA outcomes have demonstrated mixed findings.

Reference:

Neth M, Daya MR. Intravenous versus intraosseous vascular access site for medication administration during cardiac arrest: Is one preferable than the other? Resuscitation. 2021 Aug 26:S0300-9572(21)00317-8. doi: 10.1016/j.resuscitation.2021.08.018. Epub ahead of print. PMID: 34455021.