Economic impact of OPAT versus oral antibiotic therapy
Our objective was to compare economic burden between OPAT and oral therapy, accounting for direct and indirect costs and caregiver quality of life (QoL)” Krah et al (2019). Abstract: BACKGROUND: There is increasing evidence that outpatient parenteral antimicrobial therapy (OPAT) is overused for children and that outcomes with oral therapy are equivalent. Our objective was […]
Safety and effectiveness of hypodermoclysis for rehydrating children
The objective of this review is to summarize the published evidence regarding the effectiveness and safety of hypodermoclysis in comparison to intravenous fluid infusion for the rehydration of children with mild or moderate dehydration in hospital and home settings” Saganski and de Souza Freire (2019). Abstract: The objective of this review is to summarize the […]
Development of an automatic needle destroyer to prevent needlestick injuries
An automatic needle destroyer (ANDY) was developed to prevent needlestick injuries, and usability tests were conducted in several hospitals” Kim et al (2019). Abstract: OBJECTIVES: An automatic needle destroyer (ANDY) was developed to prevent needlestick injuries, and usability tests were conducted in several hospitals. The addition of extra features to the ANDY is in progress, […]
Catheter fracture in power-injectable Groshong silicone totally implantable port
Totally implantable venous access devices with Groshong silicone catheters, if inserted via the internal jugular vein, have a potential risk for late catheter fracture” Saijo et al (2019). Abstract: BACKGROUND: Totally implantable venous access devices are valuable tools for total parenteral nutrition, chemotherapy, and long-term intravenous therapy. However, late catheter fracture is a well-known complication […]
Peripheral intravenous catheter clinical decision-making aid
This study aimed to develop a decision aid to assist with clinical decision making to promote clinically indicated peripheral intravenous catheter (CIPIVC) insertion in the emergency department (ED) setting” Carr et al (2019). Abstract: BACKGROUND: It is well established that the idle peripheral intravenous catheter (PIVC) provides no therapeutic value and is a clinical, economic […]
Multidisciplinary team developed blood-borne pathogen exposure prevention bundle
Blood-borne pathogen exposure (BBPE) represents a significant safety and resource burden, with more than 380,000 events reported annually across hospitals in the United States” Gurria et al (2019). Abstract: BACKGROUND: Blood-borne pathogen exposure (BBPE) represents a significant safety and resource burden, with more than 380,000 events reported annually across hospitals in the United States. The […]
Dermacoccus nishinomiyaensis as a cause of persistent pediatric CRBSI
This case of persistent infection subsequently resolved in response to vancomycin and urokinase lock therapy that helped to maintain the catheter” Joron et al (2019). Abstract: The authors herein report a persistent Dermacoccus nishinomiyaensis catheter- related bacteremia in a 1-year-old boy with severe Hirschsprung’s disease. D. nishinomiyaensis isolates were identified by Matrix-Assisted Laser Desorption-Ionization Time-of-Light […]
Proof of concept for a strategy to reduce CLABSI rates in pediatric patients
The results of this study offer a proof of concept for a strategy to reduce CLABSI rates in pediatric patients who reside in remote and low-resource environments and are undergoing HPN” Fuchs et al 92019). Abstract: BACKGROUND: Central line-associated bloodstream infections (CLABSIs) are major sources of morbidity, death, and healthcare costs in patients who receive […]
Vascular access in children requiring maintenance haemodialysis
Here we present clinical practice recommendations for AVFs and CVLs in children with ESKD” Shroff et al (2019). Abstract: BACKGROUND: There are three principle forms of vascular access available for the treatment of children with end stage kidney disease (ESKD) by haemodialysis: tunnelled catheters placed in a central vein (central venous lines, CVLs), arteriovenous fistulas […]
Stability of mycophenolate mofetil in polypropylene 5% dextrose infusion bags
We studied the stability of 1-10 mg/mL Mycophenolate Mofetil (MMF) in polypropylene (PP) 5% dextrose infusion bags prepared from Cellcept® and a generic brand name (Micofenolato de Mofetilo Accord) at different storage temperatures. To ensure chemical compatibility during preparation, we also tested MMF sorption to the EQUASHIELD® closed-system drug transfer device (CSTD) used in this […]
Iatrogenic acquired peripheral AVF following venous catheterisation in a cat
This report describes a case of iatrogenic acquired peripheral AVF following venous catheterisation in a cat” Graziano et al (2019). Abstract: CASE SUMMARY: A 10-year-old male neutered domestic shorthair cat was presented with a 4 month history of slow, progressive swelling and intermittent multifocal bleeding of the distal right forepaw that progressively developed after cephalic […]
Parenteral versus oral iron for treatment of iron deficiency anaemia
The burden of iron deficiency anaemia during pregnancy and post-partum continues to remain high especially in India. Challenges to treatment include gastrointestinal side effects and non compliance to oral iron therapy. Newer parenteral formulations need to be explored as alternatives” Radhika et al (2019). Abstract: INTRODUCTION: The burden of iron deficiency anaemia during pregnancy and […]
Septic pulmonary embolism an undetected complication of CRBSI
Septic pulmonary embolism (SPE) may be a frequently undetected complication of central venous catheter (CVC)-related bloodstream infections (CRBSIs)” Santarpia et al (2019). Abstract: BACKGROUND: Septic pulmonary embolism (SPE) may be a frequently undetected complication of central venous catheter (CVC)-related bloodstream infections (CRBSIs). MATERIALS AND METHODS: The incidence of SPE was evaluated in a cohort of […]
Cannula-related venous thrombosis after venovenous extracorporeal membrane oxygenation
The incidence of cannula-related venous thrombosis after venovenous extracorporeal membrane oxygenation is high” Fisser et al (2019). Abstract: Objectives: Venovenous extracorporeal membrane oxygenation is indicated in patients with severe refractory acute respiratory failure. Venous thrombosis due to indwelling catheters is a frequent complication. The aim of this study was to analyze the incidence of cannula-related […]
Propofol infusion syndrome literature review
Clinicians should consider propofol infusion syndrome in cases of unexplained metabolic acidosis, ECG changes, and rhabdomyolysis” Hemphill et al (2019). Abstract: Propofol infusion syndrome is a rare, potentially fatal condition first described in children in the 1990s and later reported in adults. We provide a narrative review of what is currently known about propofol infusion […]
Complication rates in patients receiving continuous renal replacement therapy
To analyze the practice pattern of vascular access use and complication rates in patients receiving continuous renal replacement therapy from a large Chinese urban medical center” Ten et al (2019). Abstract: OBJECTIVE: To analyze the practice pattern of vascular access use and complication rates in patients receiving continuous renal replacement therapy from a large Chinese […]
Pharmacokinetics of continuous-infusion ceftazidime in febrile neutropenic children
To conduct a population pharmacokinetic analysis of continuous-infusion ceftazidime in a retrospective cohort of paediatric HSCT patients” Cojutti et al (2019). Abstract: OBJECTIVES: To conduct a population pharmacokinetic analysis of continuous-infusion ceftazidime in a retrospective cohort of paediatric HSCT patients who were empirically treated for febrile neutropenia (FN) and who underwent therapeutic drug monitoring of […]
Complications of totally implantable central venous port system insertion
The aim of the present study was to describe the procedure of totally implantable central venous port system (TICVPS) insertion performed at our center and investigate associated complications” Kim et al (2019). Abstract: The aim of the present study was to describe the procedure of totally implantable central venous port system (TICVPS) insertion performed at […]
Surveillance system for decreasing neonatal nosocomial infections
Surveillance systems are useful to reduce nosocomial infection in VLBW infants. Reduction in antibiotic and CVC use requires longer intervention time” Estañ-Capell et al (2019). Abstract: BACKGROUND: Nosocomial infection in very low birthweight (VLBW) infants is a common complication with high morbimortality. New strategies to reduce its occurrence have recently led to the development of […]
Effect of prehospital blood draws on length of stay for chest pain patients
This article provides research of cardiac biomarkers being drawn in the prehospital setting compared with the emergency department (ED) on intervals critical to the diagnosis of acute myocardial infarction” DuCharme et al (2019). Abstract: This article provides research of cardiac biomarkers being drawn in the prehospital setting compared with the emergency department (ED) on intervals […]
Information on the stability of ampicillin in total parenteral nutrition
Ampicillin (AMP) is frequently administered parenterally in critically ill patients with meningitis or endocarditis. Many of them require parallel infusion of total parenteral nutrition (TPN) admixtures. The aim of the study was to determine the physicochemical stability of AMP in TPN admixtures” Stawny et al (2019). Abstract: BACKGROUND: Ampicillin (AMP) is frequently administered parenterally in […]
Reduction of neonatal hospital-acquired infections
Central line associated blood stream infection episodes decreased from 15.2 to 2.29 episodes per 1000 catheter days (P = .004)” Flidel-Rimon et al (2019). Abstract: We instituted quality improvement program. We compare the infection rate before (2011-2012) and after (2013-2015). Central line associated blood stream infection episodes decreased from 15.2 to 2.29 episodes per 1000 catheter days […]
Prevalence and predictors of PICC-associated bloodstream infections
To evaluate the prevalence and predictors of peripherally inserted central catheter-associated bloodstream infection (PBSI) and PBSI-related death in hospitalized adult patients” Lee et al (2019). Abstract: OBJECTIVE: To evaluate the prevalence and predictors of peripherally inserted central catheter-associated bloodstream infection (PBSI) and PBSI-related death in hospitalized adult patients. MATERIALS AND METHODS: A retrospective multicenter cohort […]
Study demonstrates significant decrease in neonatal CLABSI
Although there was a significant decrease in CLABSIs and non-CLABSIs, hospital-acquired infections in preterm neonates remained high” Zipursky et al (2019). Abstract: OBJECTIVE: To determine if the reported reduction in hospital-acquired infections is due to reduced central line-associated blood stream infections (CLABSI) or non-CLABSIs. STUDY DESIGN: A retrospective cohort study design was used to describe […]
The prehospital trauma registry experience with intraosseous access
Within the registry, IO placement was relatively low (<10%) and used in casualties who received several other life-saving interventions at a higher rate than casualties who had IV access” Schauer et al (2019). Abstract: BACKGROUND: Peripheral intravenous (IV) cannulation is often difficult to obtain in a patient with hemorrhagic shock, delaying the appropriate resuscitation of […]
Prevention of venous thrombosis in paediatric acute lymphoblastic leukaemia
Secondary outcomes are central line-associated infections, patency and line replacement, superficial thrombosis, arterial events and death” O’Brien et al (2019). Abstract: Venous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute […]
Use of lidocaine on vascular pain induced by hypertonic saline infusion
To determine the analgesic efficacy and analgesic duration of lidocaine 20 mg and 40 mg on eliminating the vascular pain associated with hypertonic saline infusion” Song et al (2019). Abstract: PURPOSE: To determine the analgesic efficacy and analgesic duration of lidocaine 20 mg and 40 mg on eliminating the vascular pain associated with hypertonic saline […]
Implanted vascular access device related deep vein thrombosis in oncology patients
We sought to assess the incidence of IVAD-related upper extremity deep vein thrombosis (IVAD-related UEDVT) associated with BioFlo® IVADs (Angiodynamics, Inc.)” Suleman et al (2019). Abstract: BACKGROUND: Implanted vascular access devices (IVADs) have significantly improved the management of cancer patients. These patients are at an increased risk of venous thromboembolism and IVADs are a known […]
Spinal infections among patients with long-term central venous catheters
Spinal infections are a rare yet serious metastatic complication of bacteremia among patients with long-term central venous catheters (CVCs) for which clinicians must remain vigilant” Topan et al (2017). Abstract: Spinal infections are a rare yet serious metastatic complication of bacteremia among patients with long-term central venous catheters (CVCs) for which clinicians must remain vigilant. […]
OPAT for avoidance of hospitalisation in children
One area of increased focus for antimicrobial stewardship is outpatient parenteral antimicrobial therapy (OPAT)” Krah and Hersh (2019). Abstract: In an effort to combat antimicrobial overuse and resistance and improve patient outcomes, many paediatric hospitals have implemented antimicrobial stewardship programmes. The primary goal of these programmes is to ensure delivery of the appropriate antimicrobial at […]