Temocillin stability for OPAT
Abstract:
Background: Temocillin is an interesting alternative to carbapenems for susceptible Enterobacteriaceae. Although its use in outpatient parenteral antimicrobial therapy (OPAT) programmes has generated interest, this has been hampered by the lack of stability data.
Objectives: The purpose of the present study was to evaluate the physical and chemical stability of temocillin at the recommended dose for its use in OPAT programmes, contained in polypropylene infusion bags or polyisoprene elastomeric devices at different temperatures, and to describe a novel LC-MS/MS developed for the quantification of temocillin.
Methods: Temocillin daily dose (6 g) was diluted in 500 mL of 0.9% sodium chloride to obtain a final concentration of 12 g/L. This solution was stored at 4°C, 25°C, 32°C and 37°C for 72 h, both in polypropylene infusion bags and in polyisoprene elastomeric pumps. Physical and chemical stability were evaluated during 72 h after manufacturing. Solutions were considered stable if colour, clearness and pH remained unchanged and if the percentage of intact drug was ≥90%.
Results: Temocillin attained the chemical stability criterion of ≥90% of the original concentration for the whole experiment in both devices at 4°C, 25°C and 32°C. At 37°C, temocillin was stable for 24 h but its concentration dropped below 90% from that timepoint. No precipitation occurred and minor colour changes were observed.
Conclusions: Temocillin is stable under OPAT conditions and it would be an appropriate candidate for the treatment of patients who can be discharged to complete therapy in an OPAT programme. For this study, an LC-MS/MS method was developed.
Reference:
Fernández-Rubio B, Herrera-Hidalgo L, López-Cortés LE, Luque-Márquez R, De Alarcón A, Luque-Pardos S, Fernández-Polo A, Gutiérrez-Urbón JM, Rodríguez-Baño J, Gil-Navarro MV, Gutiérrez-Valencia A. Stability of temocillin in outpatient parenteral antimicrobial therapy: is it a real option? J Antimicrob Chemother. 2023 Aug 14:dkad251. doi: 10.1093/jac/dkad251. Epub ahead of print. PMID: 37574704.