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OPAT broad-spectrum antibiotic overuse – Full Text

"At our institution, up to 50% of select broad-spectrum OPAT regimens had potential to be narrowed, highlighting the need to re-evaluate regimens for de-escalation prior to discharge" Brenon et al (2022).

"At our institution, up to 50% of select broad-spectrum OPAT regimens had potential to be narrowed, highlighting the need to re-evaluate regimens for de-escalation prior to discharge" Brenon et al (2022).

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OPAT broad-spectrum antibiotic overuse

Abstract:

Broad-spectrum antibiotics with once-daily dosing are often chosen for outpatient parenteral antibiotic therapy (OPAT) due to convenience even when narrower-spectrum antibiotics are appropriate. At our institution, up to 50% of select broad-spectrum OPAT regimens had potential to be narrowed, highlighting the need to re-evaluate regimens for de-escalation prior to discharge.

Reference:

Brenon JR, Shulder SE, Munsiff SS, Burgoyne CM, Nagel AK, Pillinger KE. Rate of broad-spectrum antibiotic overuse in patients receiving outpatient parenteral antibiotic therapy (OPAT). Antimicrob Steward Healthc Epidemiol. 2021 Oct 22;1(1):e36. doi: 10.1017/ash.2021.204. PMID: 36168469; PMCID: PMC9495413.

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