NICU-CLABSI prevention bundle
Abstract:
Background: Central Line-Associated Bloodstream Infections (CLABSIs) in Neonatal Intensive Care Units (NICUs) significantly impact patient outcomes and healthcare costs. This study evaluates the effect of NICU-specific bundle designed to prevent CLABSIs.
Method: This retrospective single-center study was conducted at Hacettepe University Faculty of Medicine from March 2020 to August 2021. It was designed to compare 2 periods: pre-intervention and post-intervention period.
Result: The implementation of the bundles led to a significant reduction in infection rates, with CLABSIs decreasing from 29 to 4 per 1000 central line days in NICU-1 and from 14.2 to 2.6 per 1000 central line days in NICU-2. This decline was accompanied by an 80% reduction in the average healthcare cost per patient.
Conclusion: The implementation of a NICU-specific CLABSI prevention bundle significantly reduced infection rates and lowered healthcare costs by approximately 80% per patient. These findings highlight the effectiveness of structured, multidisciplinary infection control strategies in improving neonatal outcomes and resource utilization.
Reference:
Iyigun I, Aykac K, Basar P, Buyukgullu Z, Durak S, Celik HT, Yigit S, Ozsurekci Y. NICU-specific Bundle for Minimizing Central Line-Associated Bloodstream Infections: Comparative Healthcare Costs of Interventions. Am J Infect Control. 2025 Jun 15:S0196-6553(25)00427-4. doi: 10.1016/j.ajic.2025.06.010. Epub ahead of print. PMID: 40527353.