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"This case report highlights an alternative route in administering 3% saline, intraosseous vascular access, when other options have been exhausted" Juarez et al (2023)
Intraosseous hypertonic saline administration

Abstract:

Hyponatremia is a common lab finding. Symptomatology varies greatly and can depend on the degree of hyponatremia and its chronicity. Causes of hyponatremia are also vast and include heart failure, renal injury, liver disease, and gastrointestinal losses, or it can be induced by medication. Treatment depends on the suspected etiology. However, in life-threatening conditions such as seizures or coma, urgent 3% saline is required. Administration of 3% saline is usually through peripheral and central IV access. This case report highlights an alternative route in administering 3% saline, intraosseous vascular access, when other options have been exhausted.

Reference:

Juarez A, Barr M, Golden T. Hypertonic Saline Administration via Intraosseous Access During Symptomatic Hyponatremia. Cureus. 2023 Jul 11;15(7):e41731. doi: 10.7759/cureus.41731. PMID: 37575736; PMCID: PMC10415047.