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"Extravascular leakage of fluid was suspected and the PICC was reinserted. After the PICC removal from the right arm, the white-colored skin changes disappeared within a few minutes (Fig. 1C) without skin sequela" Miyamoto et al (2022).
Neonatal PICC extravasation

Extract:

“A girl weighing 564 g at 27 weeks of gestation was born by cesarean section due to fetal dysfunction. After birth, a peripherally inserted central catheter (PICC; Argyle™ PI Catheter Kit II 27G, Double Lumen, Covidien Japan, Tokyo, Japan) was indwelled from the right radial vein.

A round white skin lesion with a 5-mm diameter was observed on the patient’s right shoulder 30 h postnatally (Fig. 1A, arrow). No nodule was seen at the lesion site, and radiography revealed that it matched the PICC tip (Fig. 1B, arrowhead). At this time, a 14% glucose solution containing 1 g/kg/day of amino acids and 3 μg/kg/min of dopamine (concentration of 0.3 mg/ml) was administered via the PICC. Extravascular leakage of fluid was suspected and the PICC was reinserted. After the PICC removal from the right arm, the white-colored skin changes disappeared within a few minutes (Fig. 1C) without skin sequela.”

Reference:

Miyamoto M, Kuribayashi R, Suzumura H, Yoshihara S. Skin color change due to peripherally inserted central catheter leakage. Pediatr Neonatol. 2022 May 21:S1875-9572(22)00105-X. doi: 10.1016/j.pedneo.2022.04.005. Epub ahead of print. PMID: 35672218.