Abstract:
Objective: Catheter-related thrombosis is a common complication of central venous catheter insertion. As the use of central venous catheters increases in pediatric critical care settings, catheter-related thrombosis is becoming more common among patients who typically have multiple risk factors for thromboembolism. We aimed to investigate impact of catheter-to-vein diameter ratio on thrombosis in pediatric central venous catheterization.
Methods: Single-center, prospective study. In our study, thrombosis risk factors and patient-related factors were excluded.
Results: A total of 50 patients were included in our study. Thrombosis was observed in 34% of the patients. When comparing thrombotic and nonthrombotic patients, factors such as a low aPTT value, dialysis catheter use, certain mutations that may cause thrombosis, a high catheter-to-blood vessel diameter ratio (C/VR), and a high catheter area-to-blood vessel area ratio (C/VA) are associated with an increased risk of thrombosis. In backwards logistic regression analysis of thrombosis risk, older age, a decreased catheter area, a high C/VA ratio, and the use of dialysis catheters contributed to an increased risk of thrombosis. Patients with dialysis catheters have a 64.9 times greater risk of thrombosis than do those with central venous catheters. The C/VR, with a cut-off value of 0.197, and the C/VA, with a cut-off value of 0.088, are effective indicators in ROC analysis for thrombosis.
Conclusion: In conclusion, selecting a catheter with a diameter-to-vessel diameter ratio of less than 1:5 in normovolaemic paediatric patients should be considered as a strategy to reduce the risk of catheter-related thrombosis.
Reference:Kahveci F, Çelik NA, Uçmak H, Gurbanov A, Coşkun MK, Özen H, Yılmaz Ş, Havan M, Fitöz S, Ertem M, Kendirli T. Impact of catheter-to-vein diameter ratio on thrombosis in pediatric central venous catheterization. Front Pediatr. 2025 Aug 21;13:1631247. doi: 10.3389/fped.2025.1631247. PMID: 40918677; PMCID: PMC12408594.