Correlation between biochemistry results and CLABSI
Background: Clinical studies have not fully assessed the potential impact of patients’ biochemical indicators on the rate of positive for central venous catheter tip microorganism culture (PCMC).
Methods: Data were obtained from an online Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients who were ≥ 18 years old and had CVC tip culture results without continuous renal replacement therapy (CRRT) were included in the study. A comparison of patient characteristics and their biochemical indicators was made between negative and positive culture results.
Results: A total of 5 323 patients were included in the analysis, including 612 positive (PCMC group) and 4711 negative culture results (NCMC group). The only influence factor on PCMC in this study was the serum creatinine (Scr) [odds ratio (OR): 1.312, 95% confidence interval (CI): 1.084 to 1.590, P = 0.005], according to a binary logistic regression analysis. The cut-off value of Scr was 3.25 mg/dL. The prevalence of PCMC (27.1% vs. 9.1%, P < 0.001) and Staphylococcus aureus (43.0% vs. 18.6%, P < 0.001) for CVC tip culture results was much higher in patients with Scr ≥ 3.25 mg/dL than those Scr < 3.25 mg/dL.
Conclusion: We used the large dataset collected from MIMIC-IV to show that patients with Scr ≥ 3.25 mg/dL had an increased risk for PCMC.
Zhan Y, Xu Z. Correlation between catheter colonization of central venous catheters and clinical biochemical indicators: A retrospective analysis of the MIMIC‑IV database. Am J Infect Control. 2023 Nov 15:S0196-6553(23)00782-4. doi: 10.1016/j.ajic.2023.11.002. Epub ahead of print. PMID: 37977210.