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"We hypothesize that the impregnation of catheters with antimicrobial agents and iron chelators would increase their antimicrobial and anti-biofilm activity and inhibit microbial colony and biofilm formation" Itoh et al (2023).
Antimicrobial central venous catheters

Extract:

“From a different perspective, attempts have been made to inhibit iron, which is essential for the growth and proliferation of pathogenic microorganisms, as a strategy to increase antimicrobial activity (Schwarz et al., 2019; Scott et al., 2020). Specifically, the strategy is to use iron chelators in combination with antibacterial and antifungal agents. We hypothesize that the impregnation of catheters with antimicrobial agents and iron chelators would increase their antimicrobial and anti-biofilm activity and inhibit microbial colony and biofilm formation, resulting in reduced CRI incidence and longer catheter use, as shown in Supplementary Figure S2. The surface and lumen of the catheter are impregnated with antimicrobial and iron-chelating agents, which are assumed to inhibit bacterial and fungal colony and biofilm formation by exerting antimicrobial and iron-chelating activities on the bacteria and fungi that attach to the surface.”

Reference:

Itoh K, Tsutani H, Mitsuke Y, Iwasaki H. Potential additional effects of iron chelators on antimicrobial- impregnated central venous catheters. Front Microbiol. 2023 Aug 7;14:1210747. doi: 10.3389/fmicb.2023.1210747. PMID: 37608951; PMCID: PMC10442153.