It is often unclear what proportion of an improvement is attributable to each element of these care bundles and, as such, a single intervention such as antibiotic impregnation of CVCs might have too small an effect to be demonstrable” Khatami and Isaacs (2019).
Extract:
As Gilbert and colleagues point out,5 other infection prevention strategies in intensive care units have substantially reduced the rate of CVC-related bloodstream infection in adults8 and children, including neonates.9 It is often unclear what proportion of an improvement is attributable to each element of these care bundles and, as such, a single intervention such as antibiotic impregnation of CVCs might have too small an effect to be demonstrable. This should be a call to clinicians and researchers to develop novel and integrated strategies to prevent bloodstream and other infections in neonates and other vulnerable populations.
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Reference:
Khatami, A. and Isaacs, D. (2019) Antibiotic-impregnated central venous catheters in the neonatal intensive care unit-PREVAILing questions. The Lancet. Child & Adolescent Health. April 26th. [epub ahead of print]. doi: 10.1016/S2352-4642(19)30120-8.