Effective fluid management is crucial in inpatient care, as each patient has unique fluid and electrolyte needs. Although no universal formula or rigid guideline exists, one core principle, “clinicians should replenish identified fluid losses,” remains. These losses vary in volume and composition depending on the patient’s underlying condition. For example, a patient with extensive burns will experience significantly greater fluid loss than someone who is kept nothing by mouth (NPO) before a procedure. Similarly, fluid therapy for a patient with dehydration due to diarrhea differs from that required for a patient in hypovolemic shock from a gastrointestinal bleed.

Under normal physiological conditions, the kidneys regulate circulating volume, osmolality, and electrolyte balance by adjusting the excretion of water and solutes. The normal minimum daily water intake is derived from fluid consumption, food sources, and carbohydrate metabolism, totaling approximately 1600 mL in healthy adults, with an equivalent output through urine, sweat, respiration, and stool. Patients may require maintenance, replacement, or resuscitative fluid therapy depending on their clinical situation. Maintenance therapy addresses routine daily fluid and electrolyte needs, whereas replacement therapy corrects existing deficits due to gastrointestinal losses, bleeding, third-spacing, or other causes. Maintenance fluids come into play when oral intake is not feasible for an extended period of time. In contrast, replacement therapy corrects fluid and electrolyte deficits resulting from losses through the gastrointestinal tract, urinary system, skin, bleeding, or third-space fluid shifts. Physical examination findings and laboratory results—such as edema, skin turgor, capillary refill, weight changes, blood pressure, jugular venous pressure, urine sodium, and urine output—help guide the assessment of fluid status and determine replacement needs.

The type and rate of fluid replacement depend on the degree of depletion and patient-specific factors. Each fluid contains varying solutes, which can lead to metabolic changes. Crystalloid solutions, such as normal saline (NS), half-normal saline (½ NS), and lactated Ringer (LR) solution, are the most commonly used fluids, with the final choice guided by serum sodium or potassium levels and the presence of metabolic acidosis. Colloid solutions, such as albumin, may be reserved for refractory cases or when hypoalbuminemia contributes to volume instability. However, caution is warranted with hyperoncotic starches due to the risk of acute kidney injury. Clinicians must apply the “Four Rights” of fluid stewardship—right drug, right dosage, right duration, and right patient—to minimize risks such as volume overload, cerebral edema, hyponatremia, or hypernatremia. Thoughtful fluid selection and ongoing reassessment are critical to ensuring safe and effective fluid management.

Castera MR, Borhade MB. Fluid Management. 2025 Apr 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30335338.