What is the duration of anthracycline infusion in children with cancer?

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We aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer” Loeffen et al (2017).

Abstract:

We aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer. This study also serves as a practice example of the essential steps that need to be taken when using a previously published systematic review to develop a high-quality clinical practice guideline. Although evidence was scarce and included adult studies, the panel was able (using the Grading of Recommendations Assessment, Development and Evaluation evidence-to-decision framework) to recommend in favor of an anthracycline infusion duration of at least 1 hr (strong recommendation, very low to moderate quality of evidence). Recommending a precise optimal prolonged infusion duration was currently not possible.

Reference:

Loeffen, E.A.H., van Dalen, E.C., Mulder, R.L., van de Wetering, M.D., Kremer, L.C.M. and Tissing, W.J.E. (2017) The duration of anthracycline infusion should be at least one hour in children with cancer: A clinical practice guideline. Pediatric Blood & Cancer. October 27th. .

DOI: 10.1002/pbc.26867

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