Treatment of candida tropicalis biofilm formation

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This study was conducted to investigate the process of biofilm formation by C. tropicalis and the antifungal activity of liposomal amphotericin B (LAB) against both forming-biofilms and developed-biofilms using time-lapse imaging” Kawai et al (2017).

Abstract:

Candida species bloodstream infection such as candidemia remains a significant with high morbidity and mortality. Bloodstream infections caused by Candida species is often associated with the ability of Candida to form biofilms by using medical devices, such as central venous catheters. Non-albicans Candida species are increasing gradually in recent clinical practices.

One of the Candida species, C. tropicalis, is likely to form biofilms and is also an independent risk factor with high morbidity and mortality in hospitalized patients. This study was conducted to investigate the process of biofilm formation by C. tropicalis and the antifungal activity of liposomal amphotericin B (LAB) against both forming-biofilms and developed-biofilms using time-lapse imaging. We found that C. tropicalis has high ability of hyphae growth and gas generation due to high metabolic activity. Thus, we visually observed that C. tropicalis formed aggressive biofilms which are fast-growing type. Also, LAB acts immediately and completely inhibits against forming-biofilms. Furthermore, we demonstrated that LAB was effective against developed-biofilms of C. tropicalis by reducing the growth of hyphae and their morphology changes. The results suggest that LAB may be effective for treatment of infections caused by catheter-related C. tropicalis biofilms.

Reference:

Kawai, A., Yamagishi, Y. and Mikamo, H. (2017) Candida tropicalis Biofilm Formation and Efficacy of Liposomal Amphotericin B using time-lapse images. Japanese Journal of Infectious Diseases. July 1st. [epub ahead of print].

doi: 10.7883/yoken.JJID.2016.574.

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