Restriction of clindamycin lowers Clostridium difficile infection rates

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“Clindamycin was reduced 92.61% without an increase in other antibiotics. We identified high consumption of clindamycin as a risk factor for CDI.” Cruz-Rodríguez et al (2014).

Reference:

Cruz-Rodríguez, N.C., Hernández-García, R., Salinas-Caballero, A.G., Pérez-Rodríguez, E., Garza-González, E. and Camacho-Ortiz, A. (2014) The effect of pharmacy restriction of clindamycin on Clostridium difficile infection rates in an orthopedics ward. AJIC: American Journal of Infection Control. 42(6), p.e71-e73.

Abstract:

A high consumption of clindamycin was noted in an orthopedics ward with high rates of Clostridium difficile infection (CDI). We restricted clindamycin for the entire ward. A reduction of 88% in CDI (1.07 to 0.12 × 1,000 patients-days, P = .056) and 84% for all-cause diarrhea (2.40 to 0.38 × 1,000 patients-days, P = .021) was achieved. Clindamycin was reduced 92.61% without an increase in other antibiotics. We identified high consumption of clindamycin as a risk factor for CDI.

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