Preventing biofilm formation and associated occlusion

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“While non-coated TIVAP implanted in rats were heavily colonized by the two biofilm-forming pathogens with high percentage of occlusion, coating of TIVAP reduced their initial adherence and subsequently led to 4-log reduction in biofilm formation and reduced occlusion.” Chauhan et al (2014).

Reference:

Chauhan, A., Bernardin, A., Mussard, W., Kriegel, I., Estève, M., Ghigo, J.M., Beloin, C. and Semetey, V. (2014) Preventing biofilm formation and associated occlusion by biomimetic glycocalyx-like polymer in central venous catheters. The Journal of Infectious Diseases. May 1st. [epub ahead of print].

Abstract:

The use of catheters and other implanted devices is constantly increasing in modern medicine. Although catheters improve patients’ healthcare, the hydrophobic nature of their surface material promotes protein adsorption and cell adhesion. Catheters are therefore prone to complications such as colonization by bacterial and fungal biofilms, associated infections and thrombosis. Here we describe the in vivo efficacy of bio-inspired glycocalyx-like anti-adhesive coatings to inhibit Staphylococcus aureus and Pseudomonas aeruginosa colonization on commercial totally implantable venous access ports (TIVAP) in a clinically relevant rat model of biofilm infection. While non-coated TIVAP implanted in rats were heavily colonized by the two biofilm-forming pathogens with high percentage of occlusion, coating of TIVAP reduced their initial adherence and subsequently led to 4-log reduction in biofilm formation and reduced occlusion. Our anti-adhesive approach is a simple and generalizable strategy that could be used to minimize clinical complications associated with the use of implantable medical devices.

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