Post-exposure prophylaxis following occupational exposure to HIV and hepatitis B

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Safety IV catheter

We aim to examine the utilisation and outcome of post-exposure prophylaxis (PEP) for both HIV and hepatitis B (HBV) among HCWs” Abubakar et al (2018).

Abstract:

BACKGROUND: Healthcare workers (HCWs) have an increased risk of occupational exposure to blood-borne pathogens.

AIMS/OBJECTIVES: We aim to examine the utilisation and outcome of post-exposure prophylaxis (PEP) for both HIV and hepatitis B (HBV) among HCWs.

METHODS: This was a retrospective study conducted in a tertiary hospital in North-Western Nigeria. We reviewed data on HIV or HBV PEP given to HCWs between 2004 and 2016.

RESULTS: A total of 115 HCWs presented for PEP during the study period. Intern doctors were the most exposed group (40/115; 34.8%). There were 86/115 (74.8%) needle stick exposures. While 53/115 (46.1%) of the sources of exposure were HIV-positive, 9/115(7.83%) were HBV-positive. Zidovudine-based regimen (40/70) was the most commonly prescribed. No seroconversion occurred among those that completed PEP treatment and follow-up.

DISCUSSION: No seroconversion occurred among those that received either or both HIV and HBV PEP and completed PEP treatment.



Reference:

Abubakar, S., Iliyasu, G., Dayyab, F.M., Inuwa, S., Tudun Wada, R.A., Sadiq, N.M., Gadanya, M.A., Sheshe, A.A., Mijinyawa, M.S. and Habib, A.G. (2018) Post-exposure prophylaxis following occupational exposure to HIV and hepatitis B: an analysis of a 12-year record in a Nigerian tertiary hospital. Journal of Infection Prevention. 19(4), p.184-189.

doi: 10.1177/1757177417746733.

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