PICC occlusion in the OPAT setting

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In this retrospective study of 285 patients receiving outpatient parenteral antibiotic therapy (OPAT), duration of antibiotic, use of double-lumen catheters, and receipt of penicillin G and cloxacillin appeared to increase the risk of PICC occlusion” Lam et al (2018).

Abstract:

In this retrospective study of 285 patients receiving outpatient parenteral antibiotic therapy (OPAT), duration of antibiotic, use of double-lumen catheters, and receipt of penicillin G and cloxacillin appeared to increase the risk of PICC occlusion. Physicians should consider these factors when prescribing long-term antibiotic therapy. Further studies are needed to evaluate methods to reduce PICC occlusion, particularly when double-lumen PICCs are necessary, and when cloxacillin or penicillin G are the preferred treatment.



Reference:

Lam, P.W., Graham, C., Leis, J.A. and Daneman, N. (2018) Predictors of Peripherally Inserted Central Catheter Occlusion in the Outpatient Parenteral Antimicrobial Therapy Setting. Antimicrobial Agents and Chemotherapy. July 2nd. .

doi: 10.1128/AAC.00900-18.

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