Negative-pressure wound therapy treats epirubicin extravasation injury

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To the best of the authors’ knowledge, this is the first report of a strategy comprising the combination of negative-pressure wound therapy and a latissimus pedicle flap for reconstruction of the chest wall after soft tissue necrosis following epirubicin extravasation” Papadakis et al (2017).

Abstract

PURPOSE: Accidental extravasation is a serious iatrogenic injury among patients receiving anthracycline-containing chemotherapy. The aim of this work is to present a combination therapy for chest wall reconstruction following epirubicin extravasation.

METHODS: Herein, we report a 68-year-old woman with massive soft tissue necrosis of the anterolateral chest wall after epirubicin extravasation from a port implanted in the subclavicular area.

RESULTS: The necrotic tissue was resected, the port was removed, and negative-pressure wound therapy was applied. Three weeks later, a latissimus dorsi pedicle flap was successfully used to cover the defect.

CONCLUSIONS: To the best of the authors’ knowledge, this is the first report of a strategy comprising the combination of negative-pressure wound therapy and a latissimus pedicle flap for reconstruction of the chest wall after soft tissue necrosis following epirubicin extravasation.

Reference:

Papadakis, M., Rahmanian-Schwarz, A., Bednarek, M., Arafkas, M., Holschneider, P. and Hübner, G. (2017) Negative-pressure wound therapy and early pedicle flap reconstruction of the chest wall after epirubicin extravasation. The Journal of Vascular Access. January 31st. [Epub ahead of print].

doi: 10.5301/jva.5000654.

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