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"We present a case of a newborn girl, where intraosseous cannulation of the tibia was lifesaving. Despite following most standard recommendations, the treatment resulted in transtibial amputation due to necrosis" Oesterlie et al (2014).

Abstract:

Intraosseous needle insertion and infusion is considered an easy and reliable method of achieving a vascular access in acute circulatory collapse where other methods have not been successful within reasonable time. Complications are considered few but may be serious. We present a case of a newborn girl, where intraosseous cannulation of the tibia was lifesaving. Despite following most standard recommendations, the treatment resulted in transtibial amputation due to necrosis. We suspect that the necrosis was a consequence of extravasation of tissue-toxic calcium infusion.

Reference:

Oesterlie, G.E., Petersen, K.K., Knudsen, L. and Henriksen, T.B. (2014) Crural amputation of a newborn as a consequence of intraosseous needle insertion and calcium infusion. Pediatric Emergency Care. 2014 30(6), p.413-4.