Ascorbylperoxide (AscOOH) is a hydrogen peroxide–dependent by-product of ascorbic acid that contaminates parenteral nutrition” Mohamed et al (2016).
Background: Ascorbylperoxide (AscOOH) is a hydrogen peroxide–dependent by-product of ascorbic acid that contaminates parenteral nutrition. In a guinea pig model, it caused oxidized redox potential, increased apoptosis, and decreased alveolarization. AscOOH detoxification is carried out by glutathione peroxidase (GPX). We hypothesize that extremely preterm infants have limited capacity for AscOOH detoxification. Our objective was to determine if there is an association between an early level of urinary AscOOH and later development of bronchopulmonary dysplasia (BPD) or death.
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Materials and Methods: This prospective cohort study included 51 infants at
Results: Urinary AscOOH increased over time (P = .001) and was higher in infants who later developed BPD or died (P = .037). Compared with adults and full-term infants, total plasma glutathione concentration was low (median, 1.02 µmol/L; 25th–75th percentiles, 0.49–1.76 µmol/L), whereas GPX and glutathione reductase activities were sufficient (3.98 ± 1.25 and 0.36 ± 0.01 nmol/min/mg of protein, respectively).
Conclusion: Extremely preterm infants have low glutathione levels, which limit their capacity to detoxify AscOOH. Higher first-week urinary AscOOH levels are associated with an increased incidence of BPD or death.
Mohamed, I., Elremaly, W., Rouleau, T. and Lavoie, J-C. (2016) Ascorbylperoxide Contaminating Parenteral Nutrition Is Associated With Bronchopulmonary Dysplasia or Death in Extremely Preterm Infants. JPEN. April 1st. [epub ahead of print].
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