CLABSI diagnosis in the absence of blood culture data

0

Diagnosis of intravascular catheter infection may be affected by the definition and procedures applied in the absence of blood culture data” Austin et al (2016).

Abstract:

Background: Diagnosis of intravascular catheter infection may be affected by the definition and procedures applied in the absence of blood culture data.

Aim: To examine the extent to which different definitions of catheter infection and procedures for handling absent blood culture data can affect reported catheter infection rates.

Methods: Catheter infection rates were established in a cohort of hospitalized patients administered parenteral nutrition according to three clinical and four published definitions. Paired and unpaired comparisons were made using available case analyses, sensitivity analyses and intention-to-categorize analyses.

Findings: Complete data were available for each clinical definition (N=193), and there were missing data (4.1–26.9%) for the published definitions. In an available case analysis, the catheter infection rate was 13.0–36.8% for the clinical definitions and 2.1–12.4% for the published definitions. For the published definitions, the rate was 1.6–32.1% in a sensitivity analysis and 11.4–16.9% in an intention-to-categorize analysis, with suggestion of bias towards a higher catheter infection rate in those with missing data, in keeping with the analyses of the clinical definitions. For paired comparisons, the strength of agreement between definitions varied from ‘poor’ (Cohen’s kappa <0.21) to ‘very good’ (Cohen’s kappa ≥0.81).

Conclusion: The use of different definitions of catheter infection and procedures applied in the absence of blood culture data produced widely different catheter infection rates, which could compromise measurements or comparisons of service quality or study outcome. As such, there is a need to establish and use a valid, consistent and practical definition.

Reference:

Austin, P.D., Hand, K.S. and Elia, M. (2016) Impact of definition and procedures used for absent blood culture data on the rate of intravascular catheter infection during parenteral nutrition. The Journal of Hospital Infection. March 4th. [epub ahead of print].

DOI: http://dx.doi.org/10.1016/j.jhin.2016.02.008

Thank you to our partners for supporting IVTEAM

Share.

Comments are closed.

Free Email Updates
Join 5.5K IVTEAM members. Subscribe now and be the first to receive all the latest free updates from IVTEAM!
100% Privacy. We don't spam.