Chemotherapy-induced implantable port extravasation

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The lesion was slowly progressive with ulceration and bullae formation. A dye study showed that the catheter was intact and it was in position” Das and Gogia (2016).

Summary:

A 53-year-old woman with metastatic breast cancer receiving 3-week cycles of vinorelbine (30 mg/m2 on days 1 and 8) plus capecitabine 2000 mg/m2 (days 1–14) at the All India Institute of Medical Science (New Delhi, India) developed a large erythematous lesion at the chemotherapy port site on her left chest after day 4 of vinorelbine therapy (figure). The lesion was slowly progressive with ulceration and bullae formation. A dye study showed that the catheter was intact and it was in position. She was managed with antibiotics (oral amoxicillin–clavulanic acid 625 mg three-times daily for 7 days), subcutaneous injection of hyaluronidase 900 IU, and warm compression and showed signs of recovery.

Reference:

Das, C.K. and Gogia, A. (2016) Vinorelbine-induced chemotherapy port extravasation. The Lancet Oncology. 17(12), e568.

DOI: http://dx.doi.org/10.1016/S1470-2045(16)30556-3

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