Central venous catheter infection-induced Henoch-Schönlein purpura

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“A 69-year-old man, who had been dialyzed using a permanent central venous catheter for 2 years, presented with Henoch-Schönlein purpura and positive perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA). He was diagnosed with catheter-related infection by Staphylococcus aureus.” Gao et al (2014).

Reference:

Gao, J.J., Wei, J.M., Gao, Y.H., Li, S. and Na, Y. (2014) Central venous catheter infection-induced Henoch-Schönlein purpura in a patient on hemodialysis. Renal Failure. May 21st. [epub ahead of print].

Abstract:

A 69-year-old man, who had been dialyzed using a permanent central venous catheter for 2 years, presented with Henoch-Schönlein purpura and positive perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA). He was diagnosed with catheter-related infection by Staphylococcus aureus. After administration of antibiotic and steroid therapy, purpura disappeared and p-ANCA gradually became negative. This case supports the conclusion that infection can be pathogenesis of the vasculitis, including ANCA-positive HSP. Additionally, impregnation of catheters with antibiotics can be an effective treatment for catheter infections.

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