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"RMS is generally associated with more rapid infusion rates but can be seen following slower infusion rates" Martel et al (2020).
Excerpt:

Red man syndrome (RMS) is an anaphylactoid reaction caused by the rapid infusion of the glycopeptide antibiotic vancomycin. RMS consists of a pruritic, erythematous rash to the face, neck, and upper torso, which may also involve the extremities to a lesser degree. Symptoms may include weakness, angioedema, and chest or back pain. RMS is caused by vancomycin through the direct and non-immune-mediated release of histamine from mast cells and basophils. The amount of histamine release is generally related to the dose of vancomycin infused and the rate of infusion. RMS is generally associated with more rapid infusion rates but can be seen following slower infusion rates and after several days of transfusion. Practitioners using vancomycin should be aware of this reaction, its prevention, and treatment.

Reference:

Martel TJ, Jamil RT, King KC. Red Man Syndrome. 2020 Nov 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 29494112.