Flucloxacillin exerts antibacterial activity by binding to and inactivating penicillin-binding proteins present on the inner membrane of the bacterial cell wall” O’Connor et al (2018).
Abstract:
Flucloxacillin is a narrow spectrum beta-lactam antibiotic of the penicillin class. Flucloxacillin exerts antibacterial activity by binding to and inactivating penicillin-binding proteins present on the inner membrane of the bacterial cell wall.1 Inactivation of penicillin-binding proteins interferes with cross-linkage of peptidoglycan chains to cause interruption of the bacterial cell wall resulting in cell lysis.1 Flucloxacillin is used to treat a range of infections caused by gram-positive bacteria, including skin and soft tissue infections, osteomyelitis, and endocarditis.
Reference
O’Connor, K., Lee, A. and Fong, G. (2018) A Case Series of Patients Developing Thrombophlebitis after Administration of Flucloxacillin via a Peripheral Intravenous Catheter. The Journal of the Association for Vascular Access. 23(2), p.102-107.
DOI: https://doi.org/10.1016/j.java.2018.03.003