This case series describes potential complications associated with long-term TIVAD use, such as compromise of skin integrity, infection, or port failures” Hendriksz et al (2018).
Abstract:
Totally implantable vascular access devices (TIVADs) are commonly used in conjunction with enzyme replacement therapy (ERT) for lysosomal storage disorders (LSDs). This case series describes potential complications associated with long-term TIVAD use, such as compromise of skin integrity, infection, or port failures. Best practices and skilled specialists are essential for minimizing complications from long-term TIVAD use for ERT.
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Reference:
Hendriksz, C.J., Harmatz, P., Giugliani, R., Roberts, J. and Arul, G.S. (2018) Risks of long-term port use in enzyme replacement therapy for lysosomal storage disorders. Molecular Genetics and Metabolism Reports. 15, p.71-73.
doi: 10.1016/j.ymgmr.2018.02.007.