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"Neonates who listened to 15 minutes of music plus swaddling showed a greater absence of facial pain actions" Melo et al (2021).
Newborn invasive procedure pain reduction

Abstract:

Objectives: to evaluate the effect of music applied within ten and 15 minutes, combined with swaddling, on behavioral (facial action) and physiological (heart rate) responses to pain in full-term newborns, before and during venipuncture for blood sampling.

Methods: a randomized, triple-blind, clinical trial with 52 rooming in infants randomly assigned to four groups of 13: Experimental 1 (music [ten minutes] plus swaddling), Experimental 2 (music [15 minutes] plus swaddling), Control 1 (no music [ten minutes] plus swaddling), and Control 2 (no music [15 minutes] plus swaddling). Pain was measured using the Neonatal Facial Coding System in the basal and procedural moments.

Results: experimental 2 group showed high pain absence (p < 0.05); low heart rate mean (p < 0.0001) in the basal and procedural (antisepsis, puncture, blood squeezing/aspiration, compression) moments.

Conclusions: neonates who listened to 15 minutes of music plus swaddling showed a greater absence of facial pain actions.

Reference:

Melo GM, Cardoso MVLML, Almeida PC, Rodrigues EC. Effect of music combined with swaddling on pain in full-term newborns: randomized clinical trial. Rev Bras Enferm. 2021 Oct 25;75(3):e20210017. doi: 10.1590/0034-7167-2021-0017. PMID: 34706047.