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"A clinician should take into account knotting possibility of PICC while formulating the differential diagnosis when faced up to a malfunctioning line" Yilmaz and Çeri (2021).
Knotted PICC in premature newborn

Extract:

“By reporting this case, we want to being to the clinician’s attention that with the increasing frequency of PICC placement in newborns, a clinician should take into account knotting possibility of PICC while formulating the differential diagnosis when faced up to a malfunctioning line, in order to prevent potentially associated complications.”

Reference:

Yilmaz FH, Çeri A. A Worrisome PICC Line Complication in a Premature Newborn: Knotted Catheter. Indian J Pediatr. 2021 Jun 9. doi: 10.1007/s12098-021-03820-7. Epub ahead of print. PMID: 34106440.