IV filter recommendations differ between clinical societies
Overall, particulate matter (followed by air and microorganisms) seem to drive IV in-line filter recommendations
5 in 8 guidelines recommend using 0.2 µm and 1.2 µm IV in-line filters
4 in 8 guidelines are written by Parenteral Nutrition Societies
Only 1 in 8 guidelines evaluates the risk of protein aggregates and refers to the manufacturer’s instructions for use regarding correct IV in-line filter selection
Only 1 in 8 guidelines evaluates the risk of endotoxin and enlarged lipid droplets as a reason for using an IV in-line filter
0 in 8 guidelines consider all potential risks of infusion management, such as particulate matter, air, microorganisms, endotoxin, enlarged lipid droplets and protein aggregates.
Extract:
Over the last years, several societies, mainly parenteral nutrition societies, made recommendations regarding the use of IV in-line filters. Interestingly, the situation is not as clear or uniform as expected, and the recommendations vary widely from society to society.
In summary: