Search
"Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome" Shi et al (2023).
Managing outpatient vancomycin dosing

Abstract:

Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome. Reviewing 115 adults receiving ≥2 weeks of outpatient vancomycin, we found AUC-based and trough-based dose adjustments discordant only for troughs <12 or >16 mg/L. Selective versus universal outpatient AUC calculation would likely offer similar benefit with reduced workload.

Reference:

Shi Y, Alexander BT, Avedissian S, Bergman SJ, Cortés-Penfield N. In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range. Open Forum Infect Dis. 2023 Jan 7;10(2):ofac696. doi: 10.1093/ofid/ofac696. PMID: 36751644; PMCID: PMC9898881.