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How accurate are IV antibiotic administration times

"Overall, there were discrepancies between actual and documented antimicrobial infusion administration times" Roydhouse et al (2021).

Abstract:

Aims: Accurate documentation of medication administration time is imperative for many therapeutic decisions, including dosing of intravenous antimicrobials. The objectives were to determine (1) the discrepancy between actual and documented administration times for antimicrobial infusions and (2) whether day of the week, time of day, nurse-to-patient ratio and drug impacted accuracy of documented administration times.

Methods: Patient and dosing data were collected (Jun-Aug 2019) for 55 in-patients receiving antimicrobial infusions. “Documented” and “actual” administration times (n=660) extracted from electronic medication management systems and smart infusion pumps, respectively, were compared. Influence of the day (weekday/weekend), time of day (day/evening/night), nurse-to-patient ratio (high 1:1/low 1:5), and drug was examined. Monte Carlo simulation was used to predict the impact on dose adjustments for vancomycin using the observed administration time discrepancies compared to the actual administration time.

Results: The median discrepancy between actual and documented administration times was 16 min (range, 2-293 min), with discrepancies greater than 60 min in 7.7% of administrations. Overall, discrepancies (median ) were similar on weekends (17 [2-293] min) and weekdays (16 [2-188] min), and for high (16 [2-157] min) and low nurse-to-patient ratio wards (16 [2-293] min). Discrepancies were smallest for night administrations (p<0.05), and antimicrobials with shorter half-lives (p<0.0001). The observed discrepancies in vancomycin administration time resulted in a different dose recommendation in 58% of cases (30% higher, 28% lower).

Conclusions: Overall, there were discrepancies between actual and documented antimicrobial infusion administration times. For vancomycin, these discrepancies in administration time were predicted to result in inappropriate dose recommendations.

Reference:

Roydhouse SA, Carland JE, Debono DS, Baysari MT, Reuter SE, Staciwa AJ, Sandhu APK, Day RO, Stocker SL. Accuracy of documented administration times for intravenous antimicrobial drugs and impact on dosing decisions. Br J Clin Pharmacol. 2021 Mar 31. doi: 10.1111/bcp.14844. Epub ahead of print. PMID: 33792079.