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"We report a rare case of pleural effusion consisting of chemotherapy (chemothorax) directly injected into the pleural cavity due to the wrong placement of a central venous catheter (Porth-A-Cath) in a woman with breast cancer" Panza et al (2022).
Management of chemothorax

Abstract:

Dislocation or wrong placement of central venous catheters into the pleural cavity is rare, but if undiagnosed, may cause major, sometimes life-threatening, complications (pneumothorax, hemothorax, infection, and migration) and accidental pleural effusion due to intravenous injection of fluids containing drugs (i.e. chemotherapy, antibiotics, parenteral nutrition, other). We report a rare case of pleural effusion consisting of chemotherapy (chemothorax) directly injected into the pleural cavity due to the wrong placement of a central venous catheter (Porth-A-Cath) in a woman with breast cancer. A multidisciplinary management consisting of antidote administration, followed by removal of the venous device and washing of the pleural cavity through video-assisted thoracic surgery (VATS), avoided any major complication related to the adverse event.

Reference:

Panza T, Quercia R, Signore F, De Iaco G, Brascia D, Sampietro D, Gasbarro AR, Dell’Aera M, Lorusso V, Marulli G, De Palma A. Case report: Successful multimodal assessment and management of chemothorax. Front Surg. 2022 Jul 26;9:921968. doi: 10.3389/fsurg.2022.921968. PMID: 35959134; PMCID: PMC9360527.