“The high incidence of central venous catheter (CVC)-related deep vein thrombosis (DVT) in children and the limitations of current evidence regarding the benefit-risk balance of thromboprophylaxis as revealed by the meta-analysis, provides rationale for embarking on well-designed trials…” Male et al (2014).
Reference:
Male, C., O’Brien, S., Rodriguez, V. and Mitchell, L. (2014) Central venous catheter-related thrombosis and thromboprophylaxis in children: a systematic review and meta-analysis: discussion. Journal of Thrombosis and Haemostasis. December 16th. [epub ahead of print].
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Abstract:
We read with interest the recently published paper by Vidal et al. (1) in this journal. The paper is an important contribution to the literature and we applaud the authors for their work. The high incidence of central venous catheter (CVC)-related deep vein thrombosis (DVT) in children and the limitations of current evidence regarding the benefit-risk balance of thromboprophylaxis as revealed by the meta-analysis, provides rationale for embarking on well-designed trials to determine the safety and efficacy of anticoagulation for primary prevention of DVT in children requiring a CVC.
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