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"In conclusion, although the majority of CLABSIs appear to be preventable, our analysis shows the presence of a large minority that are either related to patient’s underlying disease process or are associated with the rigidity of standard NHSN definitions and are not preventable with standard infection prevention strategies" Hsueh et al (2022).
CLABSI definition criteria

Extract:

“Our analysis had several limitations. The CLABSI assignments were subjective. However, categorizations between the 2 reviewers were 100% consistent. Having additional institutions apply similar subgroup classifications would be useful to determine the overall preventability of NHSN-defined CLABSIs. Nonetheless, these proposed definitions are meant to be a starting point that should be refined over time as more institutions attempt similar analyses.

In conclusion, although the majority of CLABSIs appear to be preventable, our analysis shows the presence of a large minority that are either related to patient’s underlying disease process or are associated with the rigidity of standard NHSN definitions and are not preventable with standard infection prevention strategies.”

Reference:

Hsueh L, de St Maurice A, Uslan DZ. Utilizing new subdefinitions to improve the identification of preventable central-line-associated bloodstream infections (CLABSIs). Infect Control Hosp Epidemiol. 2022 Nov 23:1-2. doi: 10.1017/ice.2022.279. Epub ahead of print. PMID: 36416202.