Search

“To date, the risk factors for central venous port-related bloodstream infection (CVPBSI) in solid cancer patients have not been fully elucidated. We conducted this study in order to determine the risk factors for CVP-BSI in patients with solid cancer.” Lee et al (2014).

Reference:

Lee, G.J., Hong, S.H., Roh, S.Y., Park, S.R., Lee, M.A., Chun, H.G., Hong, Y.S., Kang, J.H., Kim, S.I., Kim, Y.J., Chun, H.J. and Oh, J.S. (2014) A case-control study to identify risk factors for totally implantable central venous port-related bloodstream infection. Cancer Research and Treatment. 46(3), p.250-60.

[ctt tweet=”Case-control study to identify risk factors for totally implantable port BSI http://ctt.ec/H1Y7K+ @ivteam #ivteam” coverup=”H1Y7K”]

Abstract:

PURPOSE: To date, the risk factors for central venous port-related bloodstream infection (CVPBSI) in solid cancer patients have not been fully elucidated. We conducted this study in order to determine the risk factors for CVP-BSI in patients with solid cancer.

MATERIALS AND METHODS: A total of 1,642 patients with solid cancer received an implantable central venous port for delivery of chemotherapy between October 2008 and December 2011 in a single center. CVP-BSI was diagnosed in 66 patients (4%). We selected a control group of 130 patients, who were individually matched with respect to age, sex, and catheter insertion time.

RESULTS: CVP-BSI occurred most frequently between September and November (37.9%). The most common pathogen was gram-positive cocci (n=35, 53.0%), followed by fungus (n=14, 21.2%). Multivariate analysis identified monthly catheter-stay as a risk factor for CVP-BSI (p=0.000), however, its risk was lower in primary gastrointestinal cancer than in other cancer (p=0.002). Initial metastatic disease and long catheter-stay were statistically significant factors affecting catheter life span (p=0.005 and p=0.000). Results of multivariate analysis showed that recent transfusion was a risk factor for mortality in patients with CVP-BSI (p=0.047).

CONCLUSION: In analysis of the results with respect to risk factors, prolonged catheter-stay should be avoided as much as possible. It is necessary to be cautious of CVP-BSI in metastatic solid cancer, especially non-gastrointestinal cancer. In addition, avoidance of unnecessary transfusion is essential in order to reduce the mortality of CVP-BSI. Finally, considering the fact that confounding factors may have affected the results, conduct of a well-designed prospective controlled study is warranted.

Click here for the full text.

Thank you to our partners for supporting IVTEAM
[slideshow_deploy id=’23788′]

Main page